BDBM50157984 CHEMBL182349::N-[13-(5-Chloro-thiophene-2-sulfonylamino)-tricyclo[8.2.1.0*3,8*]trideca-3(8),4,6-trien-5-yl]-2-diethylamino-acetamide

SMILES: CCN(CC)CC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1

InChI Key: InChIKey=YDJACBDTHCTAMI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50157984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50157984 (CHEMBL182349 | N-[13-(5-Chloro-thiophene-2-sulfony...) Show SMILES CCN(CC)CC(=O)Nc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccc(Cl)s1 |TLB:20:19:21:16.15,11:12:21:16.15,THB:22:21:19.12.18.13:16.15| Show InChI InChI=1S/C23H30ClN3O3S2/c1-3-27(4-2)14-21(28)25-19-8-7-15-11-16-5-6-17(12-18(15)13-19)23(16)26-32(29,30)22-10-9-20(24)31-22/h7-10,13,16-17,23,26H,3-6,11-12,14H2,1-2H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells				Bioorg Med Chem Lett 15: 373-8 (2004) Article DOI: 10.1016/j.bmcl.2004.10.062 BindingDB Entry DOI: 10.7270/Q2445KZQ
					More data for this Ligand-Target Pair