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SMILES: Fc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1

InChI Key: InChIKey=JKETUMKQLRSDFG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50157991   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50157991
PNG
(CHEMBL183449 | N-(5-Fluoro-tricyclo[8.2.1.0*3,8*]t...)
Show SMILES Fc1ccc2CC3CCC(Cc2c1)C3NS(=O)(=O)c1ccccc1 |TLB:12:11:13:8.7,3:4:13:8.7,THB:14:13:11.4.10.5:8.7|
Show InChI InChI=1S/C19H20FNO2S/c20-17-9-8-13-10-14-6-7-15(11-16(13)12-17)19(14)21-24(22,23)18-4-2-1-3-5-18/h1-5,8-9,12,14-15,19,21H,6-7,10-11H2
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Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells

Bioorg Med Chem Lett 15: 373-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.062
BindingDB Entry DOI: 10.7270/Q2445KZQ
More data for this
Ligand-Target Pair