null

SMILES: OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)NCc1ccccc1Cl

InChI Key: InChIKey=SRCMPGMYNOFYLZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50158089   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50158089 (CHEMBL3781306 | US10858316, Compound 3d) Show SMILES OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)NCc1ccccc1Cl Show InChI InChI=1S/C18H14ClNO5S/c19-15-8-4-1-5-11(15)10-20-26(24,25)16-9-14(18(22)23)17(21)13-7-3-2-6-12(13)16/h1-9,20-21H,10H2,(H,22,23)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	5.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF MARYLAND, BALTIMORE US Patent					Assay Description Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...				US Patent US10858316 (2020) BindingDB Entry DOI: 10.7270/Q20R9SHV
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50158089 (CHEMBL3781306 | US10858316, Compound 3d) Show SMILES OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)NCc1ccccc1Cl Show InChI InChI=1S/C18H14ClNO5S/c19-15-8-4-1-5-11(15)10-20-26(24,25)16-9-14(18(22)23)17(21)13-7-3-2-6-12(13)16/h1-9,20-21H,10H2,(H,22,23)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	5.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...				Eur J Med Chem 113: 273-92 (2016) Article DOI: 10.1016/j.ejmech.2016.02.006 BindingDB Entry DOI: 10.7270/Q2HX1FJH
					More data for this Ligand-Target Pair