Found 12 hits for monomerid = 50158536 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thymidylate synthase
(Escherichia coli) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.80E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli thymidylate synthetase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli dihydrofolate reductase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Lactobacillus casei dihydrofolate reductase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Homo sapiens (Human)) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of human dihydrofolate reductase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |
Thymidylate synthase
(Homo sapiens (Human)) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.80E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of human thymidylate synthetase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Homo sapiens (Human)) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DHFR |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Thymidylate synthase
(Escherichia coli) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/TrEMBL
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli thymidylate synthase |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Thymidylate Synthase (TS)
(Lactobacillus casei) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Lactobacillus casei thymidylate synthase |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Lactobacillus casei DHFR |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Thymidylate synthase
(Homo sapiens (Human)) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant thymidylate synthase |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Escherichia coli DHFR |
J Med Chem 47: 6893-901 (2004)
Article DOI: 10.1021/jm040123k BindingDB Entry DOI: 10.7270/Q2V40W1Z |
More data for this Ligand-Target Pair | |
Thymidylate Synthase (TS)
(Lactobacillus casei) | BDBM50158536
((S)-2-{4-[3-(2,4-Diamino-furo[2,3-d]pyrimidin-5-yl...)Show SMILES Nc1nc(N)c2c(CCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r| Show InChI InChI=1S/C21H23N5O6/c22-17-16-13(10-32-19(16)26-21(23)25-17)3-1-2-11-4-6-12(7-5-11)18(29)24-14(20(30)31)8-9-15(27)28/h4-7,10,14H,1-3,8-9H2,(H,24,29)(H,27,28)(H,30,31)(H4,22,23,25,26)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description Inhibition of Lactobacillus casei thymidylate synthetase at 37 degree C pH 7.4 |
J Med Chem 48: 5329-36 (2005)
Article DOI: 10.1021/jm058213s BindingDB Entry DOI: 10.7270/Q2RV0PF5 |
More data for this Ligand-Target Pair | |