BDBM50159006 6-(4-Benzyl-piperidin-1-ylmethyl)-6,7,8,9-tetrahydro-benzocyclohepten-5-one::CHEMBL179697
SMILES: O=C1C(CN2CCC(Cc3ccccc3)CC2)CCCc2ccccc12
InChI Key: InChIKey=ZGDALBOHMZZJLL-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50159006 (6-(4-Benzyl-piperidin-1-ylmethyl)-6,7,8,9-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 36.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Modena and Reggio Emilia Curated by ChEMBL | Assay Description Inhibitory constant against sigma receptor type 1 using 3 nM [3H]pentazocine | J Med Chem 48: 266-73 (2005) Article DOI: 10.1021/jm049433t BindingDB Entry DOI: 10.7270/Q2JH3MZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM50159006 (6-(4-Benzyl-piperidin-1-ylmethyl)-6,7,8,9-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 89.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Modena and Reggio Emilia Curated by ChEMBL | Assay Description Inhibitory constant against sigma receptor type 2 using 3 nM [3H]ditolylguanidine | J Med Chem 48: 266-73 (2005) Article DOI: 10.1021/jm049433t BindingDB Entry DOI: 10.7270/Q2JH3MZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50159006 (6-(4-Benzyl-piperidin-1-ylmethyl)-6,7,8,9-tetrahyd...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Modena and Reggio Emilia Curated by ChEMBL | Assay Description Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]8-OH-DPAT | J Med Chem 48: 266-73 (2005) Article DOI: 10.1021/jm049433t BindingDB Entry DOI: 10.7270/Q2JH3MZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50159006 (6-(4-Benzyl-piperidin-1-ylmethyl)-6,7,8,9-tetrahyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Modena and Reggio Emilia Curated by ChEMBL | Assay Description Inhibitory constant against dopamine D2 receptor using 0.2 nM [3H]-spiperone | J Med Chem 48: 266-73 (2005) Article DOI: 10.1021/jm049433t BindingDB Entry DOI: 10.7270/Q2JH3MZW | |||||||||||
More data for this Ligand-Target Pair |