BDBM50159325 3-Chloro-4-{(4S,5R)-5-[2-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-4,5-dihydro-1H-imidazol-4-yl}-phenol::CHEMBL192756

SMILES: Oc1ccc([C@@H]2N=CN[C@@H]2c2ccc(OCCN3CCCC3)cc2Cl)c(Cl)c1

InChI Key: InChIKey=JOPMKALSBFBJLF-LEWJYISDSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50159325   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM50159325 (3-Chloro-4-{(4S,5R)-5-[2-chloro-4-(2-pyrrolidin-1-...) Show SMILES Oc1ccc([C@@H]2N=CN[C@@H]2c2ccc(OCCN3CCCC3)cc2Cl)c(Cl)c1 |c:6| Show InChI InChI=1S/C21H23Cl2N3O2/c22-18-11-14(27)3-5-16(18)20-21(25-13-24-20)17-6-4-15(12-19(17)23)28-10-9-26-7-1-2-8-26/h3-6,11-13,20-21,27H,1-2,7-10H2,(H,24,25)/t20-,21+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a
Free University of Berlin Curated by ChEMBL					Assay Description Effective concentration against estrogen receptor alpha of MCF-7-2a cells				J Med Chem 48: 466-74 (2005) Article DOI: 10.1021/jm040855c BindingDB Entry DOI: 10.7270/Q20864T2
					More data for this Ligand-Target Pair
Estradiol receptor beta (ERβ) (Homo sapiens (Human))	BDBM50159325 (3-Chloro-4-{(4S,5R)-5-[2-chloro-4-(2-pyrrolidin-1-...) Show SMILES Oc1ccc([C@@H]2N=CN[C@@H]2c2ccc(OCCN3CCCC3)cc2Cl)c(Cl)c1 |c:6| Show InChI InChI=1S/C21H23Cl2N3O2/c22-18-11-14(27)3-5-16(18)20-21(25-13-24-20)17-6-4-15(12-19(17)23)28-10-9-26-7-1-2-8-26/h3-6,11-13,20-21,27H,1-2,7-10H2,(H,24,25)/t20-,21+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a
Free University of Berlin Curated by ChEMBL					Assay Description Effective concentration against estrogen receptor beta of MCF-7-2a cells				J Med Chem 48: 466-74 (2005) Article DOI: 10.1021/jm040855c BindingDB Entry DOI: 10.7270/Q20864T2
					More data for this Ligand-Target Pair