BDBM50159577 CHEMBL3786032

SMILES: Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2)c(Cl)c1

InChI Key: InChIKey=PLENDPYAKXQIAY-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50159577   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50159577 (CHEMBL3786032) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2)c(Cl)c1 Show InChI InChI=1S/C21H19ClN2O2/c1-14-9-11-26-20(14)21(25)23-17-6-7-19(18(22)12-17)24-10-8-15-4-2-3-5-16(15)13-24/h2-7,9,11-12H,8,10,13H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...				Bioorg Med Chem Lett 26: 1869-72 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B11
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50159577 (CHEMBL3786032) Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2CCc3ccccc3C2)c(Cl)c1 Show InChI InChI=1S/C21H19ClN2O2/c1-14-9-11-26-20(14)21(25)23-17-6-7-19(18(22)12-17)24-10-8-15-4-2-3-5-16(15)13-24/h2-7,9,11-12H,8,10,13H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.47E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...				Bioorg Med Chem Lett 26: 1869-72 (2016) BindingDB Entry DOI: 10.7270/Q2Z03B11
					More data for this Ligand-Target Pair