BDBM50159646 2-((R)-3-Hydroxy-pyrrolidin-1-yl)-pyrimido[2,1-a]isoquinolin-4-one::CHEMBL180023

SMILES: O[C@@H]1CCN(C1)c1cc(=O)n2ccc3ccccc3c2n1

InChI Key: InChIKey=VAFPVAFQLSKDTR-GFCCVEGCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50159646   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM50159646 (2-((R)-3-Hydroxy-pyrrolidin-1-yl)-pyrimido[2,1-a]i...) Show SMILES O[C@@H]1CCN(C1)c1cc(=O)n2ccc3ccccc3c2n1 Show InChI InChI=1S/C16H15N3O2/c20-12-6-7-18(10-12)14-9-15(21)19-8-5-11-3-1-2-4-13(11)16(19)17-14/h1-5,8-9,12,20H,6-7,10H2/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University Curated by ChEMBL					Assay Description Inhibition of DNA dependent protein kinase isolated from HeLa cells				J Med Chem 48: 569-85 (2005) Article DOI: 10.1021/jm049526a BindingDB Entry DOI: 10.7270/Q2BK1BV9
					More data for this Ligand-Target Pair