BDBM50159695 CHEMBL3787617

SMILES: CN1c2ccc(cc2CC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O)C1(N=N1)C(F)(F)F

InChI Key: InChIKey=SIDIZJFULUPVLJ-SFHVURJKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50159695   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50159695 (CHEMBL3787617) Show SMILES CN1c2ccc(cc2CC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O)C1(N=N1)C(F)(F)F |r,c:33| Show InChI InChI=1S/C24H20F3N5O3/c1-32-20-10-8-16(23(30-31-23)24(25,26)27)12-15(20)7-9-18(22(32)34)28-21(33)19-13-17(35-29-19)11-14-5-3-2-4-6-14/h2-6,8,10,12-13,18H,7,9,11H2,1H3,(H,28,33)/t18-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to Flag-tagged human RIP1 (1 to 324 residues) at 10 uM after 30 mins by fluorescence polarization assay				J Med Chem 59: 2163-78 (2016) BindingDB Entry DOI: 10.7270/Q26H4K97
					More data for this Ligand-Target Pair