BDBM50159906 1-{1-[3-(2-Chloro-5-fluoro-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one::CHEMBL182995

SMILES: CC(C)C(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)Oc1cc(F)ccc1Cl

InChI Key: InChIKey=IBFJWHIXOKNTCN-UHFFFAOYSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50159906   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50159906 (1-{1-[3-(2-Chloro-5-fluoro-phenoxy)-4-methyl-penty...) Show SMILES CC(C)C(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)Oc1cc(F)ccc1Cl Show InChI InChI=1S/C24H29ClFN3O2/c1-16(2)22(31-23-15-17(26)7-8-19(23)25)11-14-28-12-9-18(10-13-28)29-21-6-4-3-5-20(21)27-24(29)30/h3-8,15-16,18,22H,9-14H2,1-2H3,(H,27,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Organon Laboratories Ltd Curated by ChEMBL					Assay Description Binding affinity towards human opioid receptor mu 1 was determined by using [3H]-diprenorphine as radioligand expressed in Chinese hamster ovary (CHO...				Bioorg Med Chem Lett 15: 589-93 (2005) Article DOI: 10.1016/j.bmcl.2004.11.049 BindingDB Entry DOI: 10.7270/Q2K35T50
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50159906 (1-{1-[3-(2-Chloro-5-fluoro-phenoxy)-4-methyl-penty...) Show SMILES CC(C)C(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)Oc1cc(F)ccc1Cl Show InChI InChI=1S/C24H29ClFN3O2/c1-16(2)22(31-23-15-17(26)7-8-19(23)25)11-14-28-12-9-18(10-13-28)29-21-6-4-3-5-20(21)27-24(29)30/h3-8,15-16,18,22H,9-14H2,1-2H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Organon Laboratories Ltd Curated by ChEMBL					Assay Description Binding affinity towards human opioid receptor like 1 was determined by using [3H]-nociceptin as radioligand expressed in Chinese hamster ovary (CHO)...				Bioorg Med Chem Lett 15: 589-93 (2005) Article DOI: 10.1016/j.bmcl.2004.11.049 BindingDB Entry DOI: 10.7270/Q2K35T50
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50159906 (1-{1-[3-(2-Chloro-5-fluoro-phenoxy)-4-methyl-penty...) Show SMILES CC(C)C(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)Oc1cc(F)ccc1Cl Show InChI InChI=1S/C24H29ClFN3O2/c1-16(2)22(31-23-15-17(26)7-8-19(23)25)11-14-28-12-9-18(10-13-28)29-21-6-4-3-5-20(21)27-24(29)30/h3-8,15-16,18,22H,9-14H2,1-2H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Organon Laboratories Ltd Curated by ChEMBL					Assay Description Inhibitory concentration measured by cellular decreases in forskolin stimulated cAMP in CHO cells stably transfected with hORL1 receptor				Bioorg Med Chem Lett 15: 589-93 (2005) Article DOI: 10.1016/j.bmcl.2004.11.049 BindingDB Entry DOI: 10.7270/Q2K35T50
					More data for this Ligand-Target Pair