BDBM50161183 CHEMBL3787561

SMILES: Cc1cccc(c1)-c1cccc2cc(cn12)C(=O)N[C@H]1CN2CCC1CC2

InChI Key: InChIKey=SHQQVEHSZWXNPU-NRFANRHFSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50161183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM50161183 (CHEMBL3787561) Show SMILES Cc1cccc(c1)-c1cccc2cc(cn12)C(=O)N[C@H]1CN2CCC1CC2 |r,wD:19.21,(-3.44,6.01,;-2.37,5.4,;-1.04,6.17,;.3,5.41,;.31,3.87,;-1.02,3.09,;-2.36,3.86,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;.3,.77,;4.2,.04,;4.83,-1.02,;4.95,1.38,;6.49,1.4,;7.29,0,;8.9,.01,;9.7,1.42,;8.88,2.83,;7.26,2.83,;7.37,1.54,;8.62,1.52,)| Show InChI InChI=1S/C23H25N3O/c1-16-4-2-5-18(12-16)22-7-3-6-20-13-19(14-26(20)22)23(27)24-21-15-25-10-8-17(21)9-11-25/h2-7,12-14,17,21H,8-11,15H2,1H3,(H,24,27)/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.99E+3	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in xenopus oocytes preincubated for 10 mins followed by acetylcholine addition by patch clamp electr...				Eur J Med Chem 115: 94-108 (2016) BindingDB Entry DOI: 10.7270/Q2W37Z6N
					More data for this Ligand-Target Pair