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BDBM50161736 CHEMBL3785614

SMILES: O[C@@H]1[C@@H](Cn2cc(nn2)C2CC2)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12

InChI Key: InChIKey=CPEJJGJBLHVSNS-KRZJEZTLSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50161736   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50161736
PNG
(CHEMBL3785614)
Show SMILES O[C@@H]1[C@@H](Cn2cc(nn2)C2CC2)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12 |r|
Show InChI InChI=1S/C29H31ClN4O4/c30-21-2-1-3-23-25(21)20(12-16-4-6-17(7-5-16)18-8-9-18)13-34(23)29-28(37)27(36)26(35)24(38-29)15-33-14-22(31-32-33)19-10-11-19/h1-7,13-14,18-19,24,26-29,35-37H,8-12,15H2/t24-,26-,27+,28-,29-/m1/s1
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PubMed
n/an/an/an/a 359n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method

Bioorg Med Chem 24: 2242-50 (2016)


BindingDB Entry DOI: 10.7270/Q25D8TQP
More data for this
Ligand-Target Pair