BDBM50162261 3,4-dimethyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03,7]pentadeca-2(10),3,5,8-tetraen-9-yl ether::CHEMBL361786

SMILES: Cc1ccnc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)c1C

InChI Key: InChIKey=MFZNONRIQYSLMZ-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50162261 (3,4-dimethyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazate...) Show SMILES Cc1ccnc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)c1C |(-2.17,-6.93,;-.83,-6.16,;.51,-6.93,;1.83,-6.16,;1.83,-4.62,;.51,-3.87,;.51,-2.33,;-.83,-1.56,;-.83,-.02,;.49,.74,;.49,2.29,;1.66,3.35,;1.03,4.71,;-.49,4.57,;-.83,3.07,;-2.15,2.28,;-3.49,2.96,;-2.85,1.52,;-4.43,1.52,;-3.48,-.03,;-4.82,.74,;-4.82,2.28,;-2.15,.74,;3.17,3.05,;3.66,1.59,;5.18,1.28,;6.19,2.45,;5.69,3.91,;4.18,4.2,;-.83,-4.62,;-2.15,-3.83,)| Show InChI InChI=1S/C25H25N5O/c1-15-12-13-26-20(16(15)2)14-31-25-22-18-10-8-17(9-11-18)21(22)24-28-27-23(30(24)29-25)19-6-4-3-5-7-19/h3-7,12-13,17-18H,8-11,14H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 subtype expressed in L (tk-) cells				J Med Chem 48: 1367-83 (2005) Article DOI: 10.1021/jm040883v BindingDB Entry DOI: 10.7270/Q2ZW1KD2
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50162261 (3,4-dimethyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazate...) Show SMILES Cc1ccnc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)c1C |(-2.17,-6.93,;-.83,-6.16,;.51,-6.93,;1.83,-6.16,;1.83,-4.62,;.51,-3.87,;.51,-2.33,;-.83,-1.56,;-.83,-.02,;.49,.74,;.49,2.29,;1.66,3.35,;1.03,4.71,;-.49,4.57,;-.83,3.07,;-2.15,2.28,;-3.49,2.96,;-2.85,1.52,;-4.43,1.52,;-3.48,-.03,;-4.82,.74,;-4.82,2.28,;-2.15,.74,;3.17,3.05,;3.66,1.59,;5.18,1.28,;6.19,2.45,;5.69,3.91,;4.18,4.2,;-.83,-4.62,;-2.15,-3.83,)| Show InChI InChI=1S/C25H25N5O/c1-15-12-13-26-20(16(15)2)14-31-25-22-18-10-8-17(9-11-18)21(22)24-28-27-23(30(24)29-25)19-6-4-3-5-7-19/h3-7,12-13,17-18H,8-11,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 subtype expressed in L (tk-) cells				J Med Chem 48: 1367-83 (2005) Article DOI: 10.1021/jm040883v BindingDB Entry DOI: 10.7270/Q2ZW1KD2
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50162261 (3,4-dimethyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazate...) Show SMILES Cc1ccnc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)c1C |(-2.17,-6.93,;-.83,-6.16,;.51,-6.93,;1.83,-6.16,;1.83,-4.62,;.51,-3.87,;.51,-2.33,;-.83,-1.56,;-.83,-.02,;.49,.74,;.49,2.29,;1.66,3.35,;1.03,4.71,;-.49,4.57,;-.83,3.07,;-2.15,2.28,;-3.49,2.96,;-2.85,1.52,;-4.43,1.52,;-3.48,-.03,;-4.82,.74,;-4.82,2.28,;-2.15,.74,;3.17,3.05,;3.66,1.59,;5.18,1.28,;6.19,2.45,;5.69,3.91,;4.18,4.2,;-.83,-4.62,;-2.15,-3.83,)| Show InChI InChI=1S/C25H25N5O/c1-15-12-13-26-20(16(15)2)14-31-25-22-18-10-8-17(9-11-18)21(22)24-28-27-23(30(24)29-25)19-6-4-3-5-7-19/h3-7,12-13,17-18H,8-11,14H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric acid A receptor alpha2-beta3-gamma2 subtype expressed in L (tk-) cells				J Med Chem 48: 1367-83 (2005) Article DOI: 10.1021/jm040883v BindingDB Entry DOI: 10.7270/Q2ZW1KD2
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50162261 (3,4-dimethyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazate...) Show SMILES Cc1ccnc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)c1C |(-2.17,-6.93,;-.83,-6.16,;.51,-6.93,;1.83,-6.16,;1.83,-4.62,;.51,-3.87,;.51,-2.33,;-.83,-1.56,;-.83,-.02,;.49,.74,;.49,2.29,;1.66,3.35,;1.03,4.71,;-.49,4.57,;-.83,3.07,;-2.15,2.28,;-3.49,2.96,;-2.85,1.52,;-4.43,1.52,;-3.48,-.03,;-4.82,.74,;-4.82,2.28,;-2.15,.74,;3.17,3.05,;3.66,1.59,;5.18,1.28,;6.19,2.45,;5.69,3.91,;4.18,4.2,;-.83,-4.62,;-2.15,-3.83,)| Show InChI InChI=1S/C25H25N5O/c1-15-12-13-26-20(16(15)2)14-31-25-22-18-10-8-17(9-11-18)21(22)24-28-27-23(30(24)29-25)19-6-4-3-5-7-19/h3-7,12-13,17-18H,8-11,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 subtype expressed in L (tk-) cells				J Med Chem 48: 1367-83 (2005) Article DOI: 10.1021/jm040883v BindingDB Entry DOI: 10.7270/Q2ZW1KD2
					More data for this Ligand-Target Pair