BDBM50162888 CHEMBL426604::[2-(4-Fluoro-phenyl)-ethyl]-(1H-imidazol-4-ylmethyl)-(4-phenoxy-benzyl)-amine
SMILES: Fc1ccc(CCN(Cc2cnc[nH]2)Cc2ccc(Oc3ccccc3)cc2)cc1
InChI Key: InChIKey=GSHROJORMPAUBU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human)) | BDBM50162888 (CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation Curated by ChEMBL | Assay Description Inhibition of Farnesyltransferase | Bioorg Med Chem Lett 15: 1713-9 (2005) Article DOI: 10.1016/j.bmcl.2005.01.042 BindingDB Entry DOI: 10.7270/Q24F1Q7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM50162888 (CHEMBL426604 | [2-(4-Fluoro-phenyl)-ethyl]-(1H-imi...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation Curated by ChEMBL | Assay Description Inhibition of Geranylgeranyl transferase type I | Bioorg Med Chem Lett 15: 1713-9 (2005) Article DOI: 10.1016/j.bmcl.2005.01.042 BindingDB Entry DOI: 10.7270/Q24F1Q7J | |||||||||||
More data for this Ligand-Target Pair |