BDBM50162995 3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4-[1-(1,4,4a,8a-tetrahydro-naphthalen-2-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL367107
SMILES: O=C1NC(=O)C(=C1c1cn(-c2ccc3ccccc3c2)c2ccccc12)c1nn(CCCN2CCCC2)c2ccccc12
InChI Key: InChIKey=AOIKKLIBKSSHQP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of Potassium channel HERG | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATP | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C, gamma (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2 | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM50162995 (3-[1-(1,2-Dihydro-pyridin-2-yl)-1H-indazol-3-yl]-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of rabbit Glycogen synthase kinase-3 beta | J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX | |||||||||||
More data for this Ligand-Target Pair |