BDBM50163105 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid ethylamide::CHEMBL175094
SMILES: CCNS(=O)(=O)c1ccc2C[C@H](CF)NCc2c1
InChI Key: InChIKey=UKWVXNMBQJTJOS-LLVKDONJSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenylethanolamine N-methyltransferase (Homo sapiens (Human)) | BDBM50163105 ((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMet | J Med Chem 48: 1806-12 (2005) Article DOI: 10.1021/jm049594x BindingDB Entry DOI: 10.7270/Q2TX3DW4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Alpha-2A adrenergic receptor [16-465] (Rattus norvegicus (rat)) | BDBM50163105 ((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description In vitro binding affinity against rat Alpha-2 adrenergic receptor using [3H]-clonidine | J Med Chem 48: 1806-12 (2005) Article DOI: 10.1021/jm049594x BindingDB Entry DOI: 10.7270/Q2TX3DW4 | |||||||||||
More data for this Ligand-Target Pair |