BDBM50163759 CHEMBL3798587

SMILES: CN1CCCC11CCN(CC1)c1c(Cl)cncc1-c1ccc2N(C)S(=O)(=O)Cc2c1

InChI Key: InChIKey=SIWAQIAXQNZGEJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50163759 (CHEMBL3798587) Show SMILES CN1CCCC11CCN(CC1)c1c(Cl)cncc1-c1ccc2N(C)S(=O)(=O)Cc2c1 Show InChI InChI=1S/C22H27ClN4O2S/c1-25-9-3-6-22(25)7-10-27(11-8-22)21-18(13-24-14-19(21)23)16-4-5-20-17(12-16)15-30(28,29)26(20)2/h4-5,12-14H,3,6-11,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay				J Med Chem 59: 1078-101 (2016) BindingDB Entry DOI: 10.7270/Q29025P6
					More data for this Ligand-Target Pair