BDBM50163788 CHEMBL3798568

SMILES: Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c(c1N1CCC2(CNC(=O)O2)CC1)C(F)(F)F

InChI Key: InChIKey=FZQAZSRDRZGHTP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163788   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50163788 (CHEMBL3798568) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c(c1N1CCC2(CNC(=O)O2)CC1)C(F)(F)F Show InChI InChI=1S/C23H23F3N6O2/c1-31-12-16(10-30-31)14-2-4-15(5-3-14)17-11-28-20(27)18(23(24,25)26)19(17)32-8-6-22(7-9-32)13-29-21(33)34-22/h2-5,10-12H,6-9,13H2,1H3,(H2,27,28)(H,29,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay				J Med Chem 59: 1078-101 (2016) BindingDB Entry DOI: 10.7270/Q29025P6
					More data for this Ligand-Target Pair