BDBM50163900 (E)-3-[4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-phenyl]-acrylic acid::CHEMBL182735

SMILES: CC(C)c1c[nH]c2ccc(Oc3c(cc(\C=C\C(O)=O)cc3C(F)(F)F)C(F)(F)F)cc12

InChI Key: InChIKey=ZOZISPMEYNRQNA-ZZXKWVIFSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thyroid Hormone Receptor (TR-alpha)/(TR-beta) (Homo sapiens (Human))	BDBM50163900 ((E)-3-[4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-tr...) Show SMILES CC(C)c1c[nH]c2ccc(Oc3c(cc(\C=C\C(O)=O)cc3C(F)(F)F)C(F)(F)F)cc12 Show InChI InChI=1S/C22H17F6NO3/c1-11(2)15-10-29-18-5-4-13(9-14(15)18)32-20-16(21(23,24)25)7-12(3-6-19(30)31)8-17(20)22(26,27)28/h3-11,29H,1-2H3,(H,30,31)/b6-3+	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
BAYER HealthCare AG Curated by ChEMBL					Assay Description Agonist activity towards thyroid hormone receptor expressed in human HepG2 cells				Bioorg Med Chem Lett 15: 1835-40 (2005) Article DOI: 10.1016/j.bmcl.2005.02.028 BindingDB Entry DOI: 10.7270/Q290239F
					More data for this Ligand-Target Pair