Found 6 hits for monomerid = 50163923 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.4 expressed in HEK293 cells assessed as inward peak current by ion-works quattro patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inward peak current by ion-works quattro patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50163923
(CHEMBL3799252)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@]1([H])CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC2=O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@]2([H])CCCN2C(=O)[C@@]([H])(NC3=O)[C@@H](C)CC)C(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C178H273N53O46S7/c1-14-93(10)141-175(277)231-64-35-50-132(231)170(272)217-123(77-138(243)244)159(261)214-119(73-133(183)236)155(257)215-122(76-137(241)242)158(260)204-107(45-26-30-59-182)149(251)220-128-85-282-279-82-125(163(265)206-105(43-24-28-57-180)146(248)212-116(70-98-51-53-101(235)54-52-98)161(263)227-139(91(6)7)171(273)209-112(143(185)245)68-96-36-17-15-18-37-96)222-153(255)117(71-99-78-196-103-41-22-21-40-102(99)103)213-147(249)104(42-23-27-56-179)203-154(256)118(72-100-79-192-88-198-100)218-173(275)142(94(11)233)229-151(253)109(47-32-61-194-177(188)189)205-162(264)124(81-232)219-166(268)129-86-283-284-87-130(168(270)228-141)221-148(250)106(44-25-29-58-181)201-145(247)108(46-31-60-193-176(186)187)202-150(252)110(55-65-278-13)207-152(254)115(69-97-38-19-16-20-39-97)200-135(238)80-197-144(246)113(66-89(2)3)210-165(267)127(223-157(259)121(75-136(239)240)199-95(12)234)84-281-280-83-126(224-167(128)269)164(266)208-111(48-33-62-195-178(190)191)174(276)230-63-34-49-131(230)169(271)216-120(74-134(184)237)156(258)211-114(67-90(4)5)160(262)226-140(92(8)9)172(274)225-129/h15-22,36-41,51-54,78-79,88-94,104-132,139-142,196,232-233,235H,14,23-35,42-50,55-77,80-87,179-182H2,1-13H3,(H2,183,236)(H2,184,237)(H2,185,245)(H,192,198)(H,197,246)(H,199,234)(H,200,238)(H,201,247)(H,202,252)(H,203,256)(H,204,260)(H,205,264)(H,206,265)(H,207,254)(H,208,266)(H,209,273)(H,210,267)(H,211,258)(H,212,248)(H,213,249)(H,214,261)(H,215,257)(H,216,271)(H,217,272)(H,218,275)(H,219,268)(H,220,251)(H,221,250)(H,222,255)(H,223,259)(H,224,269)(H,225,274)(H,226,262)(H,227,263)(H,228,270)(H,229,253)(H,239,240)(H,241,242)(H,243,244)(H4,186,187,193)(H4,188,189,194)(H4,190,191,195)/t93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,139-,140-,141-,142-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inward peak current by ion-works quattro patch clamp electrophysiology method |
J Med Chem 59: 2704-17 (2016)
BindingDB Entry DOI: 10.7270/Q2S184D5 |
More data for this
Ligand-Target Pair | |
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