BDBM50164023 CHEMBL180307::Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide

SMILES: Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccsc1)S(=O)(=O)c1cccnc1

InChI Key: InChIKey=VZFHWZARTPYKEO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164023   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50164023 (CHEMBL180307 | Pyridine-3-sulfonic acid [6-cyano-1...) Show SMILES Cn1cncc1CN1CC(Cc2cc(ccc12)C#N)N(Cc1ccsc1)S(=O)(=O)c1cccnc1 Show InChI InChI=1S/C25H24N6O2S2/c1-29-18-28-12-23(29)16-30-15-22(10-21-9-19(11-26)4-5-25(21)30)31(14-20-6-8-34-17-20)35(32,33)24-3-2-7-27-13-24/h2-9,12-13,17-18,22H,10,14-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human farnesyltransferase				Bioorg Med Chem Lett 15: 1895-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.004 BindingDB Entry DOI: 10.7270/Q2RB75CJ
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