BDBM50164111 6-(4-Hydroxy-2,6-dimethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL369732

SMILES: Cc1cc(O)cc(C)c1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O

InChI Key: InChIKey=AIKONZJJWSDYSZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164111   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164111 (6-(4-Hydroxy-2,6-dimethyl-phenyl)-8-methyl-2-pheny...) Show SMILES Cc1cc(O)cc(C)c1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(4.99,-1.27,;4.99,.27,;6.32,1.05,;6.31,2.58,;7.64,3.38,;4.95,3.36,;3.64,2.58,;2.29,3.33,;3.65,1.05,;2.33,.27,;.99,1.02,;-.33,.26,;-1.67,1.02,;-3,.23,;-3,-1.31,;-4.33,-2.08,;-5.69,-1.31,;-6.99,-2.08,;-8.32,-1.33,;-8.35,.23,;-7,1,;-5.66,.23,;-1.67,-2.08,;-.33,-1.29,;1,-2.05,;1,-3.6,;2.33,-1.29,;3.67,-2.05,)| Show InChI InChI=1S/C22H20N4O2/c1-13-9-17(27)10-14(2)19(13)18-11-15-12-23-22(24-16-7-5-4-6-8-16)25-20(15)26(3)21(18)28/h4-12,27H,1-3H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair