BDBM50164112 6-(3-Aminomethyl-2,6-dichloro-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL181822

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(CN)c2Cl)c1=O

InChI Key: InChIKey=VZXKAOPLYZEOGZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164112   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164112 (6-(3-Aminomethyl-2,6-dichloro-phenyl)-8-methyl-2-p...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(CN)c2Cl)c1=O |(.89,-3.84,;.89,-2.31,;-.46,-1.53,;-1.8,-2.32,;-3.13,-1.55,;-4.46,-2.32,;-5.79,-1.56,;-5.79,-.02,;-7.12,.75,;-8.47,-.02,;-8.47,-1.57,;-7.12,-2.32,;-3.13,-.01,;-1.8,.79,;-.46,,;.86,.79,;2.2,.02,;3.53,.79,;4.87,.04,;4.88,-1.52,;6.2,.79,;6.19,2.35,;4.84,3.11,;4.83,4.65,;6.15,5.43,;3.53,2.33,;2.17,3.1,;2.22,-1.53,;3.55,-2.3,)| Show InChI InChI=1S/C21H17Cl2N5O/c1-28-19-13(11-25-21(27-19)26-14-5-3-2-4-6-14)9-15(20(28)29)17-16(22)8-7-12(10-24)18(17)23/h2-9,11H,10,24H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair