BDBM50164132 6-(2,6-Dimethoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL180673

SMILES: COc1cccc(OC)c1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O

InChI Key: InChIKey=JRPLMLPNEXPGSO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164132   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164132 (6-(2,6-Dimethoxy-phenyl)-8-methyl-2-phenylamino-8H...) Show SMILES COc1cccc(OC)c1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(6.31,-2.01,;4.95,-1.24,;4.95,.3,;6.28,1.07,;6.28,2.61,;4.92,3.38,;3.62,2.59,;2.27,3.35,;2.25,4.89,;3.62,1.07,;2.29,.28,;.96,1.05,;-.37,.27,;-1.7,1.04,;-3.03,.27,;-3.03,-1.28,;-4.36,-2.05,;-5.71,-1.28,;-5.68,.26,;-7.02,1.03,;-8.37,.25,;-8.35,-1.31,;-7.02,-2.06,;-1.7,-2.05,;-.37,-1.27,;.96,-2.04,;.96,-3.58,;2.31,-1.26,;3.65,-2.03,)| Show InChI InChI=1S/C22H20N4O3/c1-26-20-14(13-23-22(25-20)24-15-8-5-4-6-9-15)12-16(21(26)27)19-17(28-2)10-7-11-18(19)29-3/h4-13H,1-3H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair