BDBM50164149 6-(2,6-Dichloro-4-hydroxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL179898

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cc(O)cc2Cl)c1=O

InChI Key: InChIKey=GXOUJVQEFADKQO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164149 (6-(2,6-Dichloro-4-hydroxy-phenyl)-8-methyl-2-pheny...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cc(O)cc2Cl)c1=O |(1,-3.6,;1,-2.05,;-.33,-1.29,;-1.67,-2.08,;-3,-1.31,;-4.33,-2.08,;-5.69,-1.31,;-6.99,-2.08,;-8.32,-1.33,;-8.35,.23,;-7,1,;-5.66,.23,;-3,.23,;-1.67,1.02,;-.33,.26,;.99,1.02,;2.33,.27,;3.65,1.05,;3.64,2.58,;2.29,3.33,;4.95,3.36,;6.31,2.58,;7.64,3.38,;6.32,1.05,;4.99,.27,;4.99,-1.27,;2.33,-1.29,;3.67,-2.05,)| Show InChI InChI=1S/C20H14Cl2N4O2/c1-26-18-11(10-23-20(25-18)24-12-5-3-2-4-6-12)7-14(19(26)28)17-15(21)8-13(27)9-16(17)22/h2-10,27H,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair