BDBM50165642 (4-{5-[2-Chloro-4-(3-phenyl-acryloylamino)-phenyl]-furan-2-yl}-thiazol-2-yl)-acetic acid::2-(4-(5-(2-chloro-4-cinnamamidophenyl)furan-2-yl)thiazol-2-yl)acetic acid::CHEMBL381461
SMILES: OC(=O)Cc1nc(cs1)-c1ccc(o1)-c1ccc(NC(=O)\C=C\c2ccccc2)cc1Cl
InChI Key: InChIKey=XSRZFGPWBAVYOB-IZZDOVSWSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heparanase (Homo sapiens (Human)) | BDBM50165642 ((4-{5-[2-Chloro-4-(3-phenyl-acryloylamino)-phenyl]...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
Sharif University of Technology Curated by ChEMBL | Assay Description Inhibition of heparanase | Eur J Med Chem 43: 548-56 (2008) Article DOI: 10.1016/j.ejmech.2007.04.014 BindingDB Entry DOI: 10.7270/Q2PC33KM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heparanase (Homo sapiens (Human)) | BDBM50165642 ((4-{5-[2-Chloro-4-(3-phenyl-acryloylamino)-phenyl]...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R&D Ltd Curated by ChEMBL | Assay Description In vitro inhibitory concentration against human Heparanase | Bioorg Med Chem Lett 15: 2295-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.014 BindingDB Entry DOI: 10.7270/Q2BP029G | |||||||||||
More data for this Ligand-Target Pair |