BDBM50166423 CHEMBL3797696

SMILES: Clc1cccc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1

InChI Key: InChIKey=BRIHERZGZCDIMX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50166423 (CHEMBL3797696) Show SMILES Clc1cccc(Cl)c1CNC(=O)c1ccc2[nH]nc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H14Cl2N4O/c21-16-2-1-3-17(22)15(16)11-24-20(27)13-4-5-18-14(10-13)19(26-25-18)12-6-8-23-9-7-12/h1-10H,11H2,(H,24,27)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	154	n/a	n/a	n/a	n/a	n/a	n/a
Green Valley Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured aft...				Bioorg Med Chem Lett 26: 2600-4 (2016) Article DOI: 10.1016/j.bmcl.2016.04.029 BindingDB Entry DOI: 10.7270/Q2H99731
					More data for this Ligand-Target Pair