BDBM50166512 3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-5,6-dimethyl-3H-pyrimidin-4-one::CHEMBL193498
SMILES: Cc1nc(-c2ccccc2O)n(CCc2cccc(F)c2)c(=O)c1C
InChI Key: InChIKey=FHWPMBMRZSDIGY-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Calcium-sensing receptor (CaSR) (Homo sapiens (Human)) | BDBM50166512 (3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibitory concentration was evaluated for in vitro calcilytic activity against human calcium receptor | Bioorg Med Chem Lett 15: 2537-40 (2005) Article DOI: 10.1016/j.bmcl.2005.03.054 BindingDB Entry DOI: 10.7270/Q26Q1WRQ | |||||||||||
More data for this Ligand-Target Pair |