null

SMILES: CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1

InChI Key: InChIKey=HLWKISDEYFIAEV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50166574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50166574 (CHEMBL3798598) Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1 Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay				Bioorg Med Chem Lett 26: 2670-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.009 BindingDB Entry DOI: 10.7270/Q2CJ8GDR
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM50166574 (CHEMBL3798598) Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1 Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP1 receptor expressed in human Chem1 cell membrane by scintillation proximity assay				Bioorg Med Chem Lett 26: 2670-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.009 BindingDB Entry DOI: 10.7270/Q2CJ8GDR
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50166574 (CHEMBL3798598) Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1 Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in human Chem1 cell membrane by scintillation proximity assay				Bioorg Med Chem Lett 26: 2670-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.009 BindingDB Entry DOI: 10.7270/Q2CJ8GDR
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50166574 (CHEMBL3798598) Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1 Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in human Chem1 cell membrane by scintillation proximity assay				Bioorg Med Chem Lett 26: 2670-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.009 BindingDB Entry DOI: 10.7270/Q2CJ8GDR
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50166574 (CHEMBL3798598) Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1 Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p...				Bioorg Med Chem Lett 26: 2670-5 (2016) Article DOI: 10.1016/j.bmcl.2016.04.009 BindingDB Entry DOI: 10.7270/Q2CJ8GDR
					More data for this Ligand-Target Pair