BDBM50166913 CHEMBL3797795

SMILES: CC(=O)Nc1ccc(cc1)-c1ncnc2n(C)c(cc12)C(N)=O

InChI Key: InChIKey=APLUVSDJOJLJMG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50166913   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50166913 (CHEMBL3797795) Show SMILES CC(=O)Nc1ccc(cc1)-c1ncnc2n(C)c(cc12)C(N)=O Show InChI InChI=1S/C16H15N5O2/c1-9(22)20-11-5-3-10(4-6-11)14-12-7-13(15(17)23)21(2)16(12)19-8-18-14/h3-8H,1-2H3,(H2,17,23)(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of JAK2 in GMCSF-stimulated human TF1 cells assessed as suppression of STAT5 phosphorylation preincubated for 2 hrs followed by GMCSF stim...				Bioorg Med Chem Lett 26: 2936-2941 (2016) Article DOI: 10.1016/j.bmcl.2016.04.027 BindingDB Entry DOI: 10.7270/Q2GB25ZS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50166913 (CHEMBL3797795) Show SMILES CC(=O)Nc1ccc(cc1)-c1ncnc2n(C)c(cc12)C(N)=O Show InChI InChI=1S/C16H15N5O2/c1-9(22)20-11-5-3-10(4-6-11)14-12-7-13(15(17)23)21(2)16(12)19-8-18-14/h3-8H,1-2H3,(H2,17,23)(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr...				Bioorg Med Chem Lett 26: 2936-2941 (2016) Article DOI: 10.1016/j.bmcl.2016.04.027 BindingDB Entry DOI: 10.7270/Q2GB25ZS
					More data for this Ligand-Target Pair