BDBM50166919 CHEMBL3798740

SMILES: CCC(=O)Nc1ccc(cc1)-c1ncnc2n(C)c(cc12)C(=O)OCc1ccccc1

InChI Key: InChIKey=HDYZZNRXIIIKEF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50166919 (CHEMBL3798740) Show SMILES CCC(=O)Nc1ccc(cc1)-c1ncnc2n(C)c(cc12)C(=O)OCc1ccccc1 Show InChI InChI=1S/C24H22N4O3/c1-3-21(29)27-18-11-9-17(10-12-18)22-19-13-20(28(2)23(19)26-15-25-22)24(30)31-14-16-7-5-4-6-8-16/h4-13,15H,3,14H2,1-2H3,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	531	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr...				Bioorg Med Chem Lett 26: 2936-2941 (2016) Article DOI: 10.1016/j.bmcl.2016.04.027 BindingDB Entry DOI: 10.7270/Q2GB25ZS
					More data for this Ligand-Target Pair