BDBM50166936 CHEMBL3800186

SMILES: Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)C(C)(C)C)cc1)C(N)=O

InChI Key: InChIKey=XDVAZFKKAPLYBJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50166936   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50166936 (CHEMBL3800186) Show SMILES Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)C(C)(C)C)cc1)C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-19(2,3)18(26)23-12-7-5-11(6-8-12)15-13-9-14(16(20)25)24(4)17(13)22-10-21-15/h5-10H,1-4H3,(H2,20,25)(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr...				Bioorg Med Chem Lett 26: 2936-2941 (2016) Article DOI: 10.1016/j.bmcl.2016.04.027 BindingDB Entry DOI: 10.7270/Q2GB25ZS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50166936 (CHEMBL3800186) Show SMILES Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)C(C)(C)C)cc1)C(N)=O Show InChI InChI=1S/C19H21N5O2/c1-19(2,3)18(26)23-12-7-5-11(6-8-12)15-13-9-14(16(20)25)24(4)17(13)22-10-21-15/h5-10H,1-4H3,(H2,20,25)(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of JAK2 in GMCSF-stimulated human TF1 cells assessed as suppression of STAT5 phosphorylation preincubated for 2 hrs followed by GMCSF stim...				Bioorg Med Chem Lett 26: 2936-2941 (2016) Article DOI: 10.1016/j.bmcl.2016.04.027 BindingDB Entry DOI: 10.7270/Q2GB25ZS
					More data for this Ligand-Target Pair