BDBM50167805 4',5'-dibutyl-1-(4-fluorophenyl)-4a-methyl-(4'R,4aS,5'R)-spiro[4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazole-5,2'-(dihydro[1,3]dioxolane)]::CHEMBL196975
SMILES: CCCC[C@H]1OC2(CCCC3=Cc4c(C[C@]23C)cnn4-c2ccc(F)cc2)O[C@@H]1CCCC
InChI Key: InChIKey=CMJPJNBMUFZCAM-PFBJBMPXSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50167805 (4',5'-dibutyl-1-(4-fluorophenyl)-4a-methyl-(4'R,4a...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human glucocorticoid receptor alpha isoform | Bioorg Med Chem Lett 15: 2926-31 (2005) Article DOI: 10.1016/j.bmcl.2005.03.027 BindingDB Entry DOI: 10.7270/Q2X34X0Q | |||||||||||
More data for this Ligand-Target Pair |