BDBM50167816 1-(4-fluorophenyl)-4',4a-dimethyl-(4'R,4aS,5'S)-spiro[1,4,4a,5,6,7-hexahydrocyclopenta[f]indazole-5,2'-(dihydro-4'H-[1,3]dioxane)]::CHEMBL380790

SMILES: C[C@@H]1CCO[C@@]2(CCC3=Cc4c(C[C@]23C)cnn4-c2ccc(F)cc2)O1

InChI Key: InChIKey=UFBTXBXBMIBAIJ-OREJSRFESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50167816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50167816 (1-(4-fluorophenyl)-4',4a-dimethyl-(4'R,4aS,5'S)-sp...) Show SMILES C[C@@H]1CCO[C@@]2(CCC3=Cc4c(C[C@]23C)cnn4-c2ccc(F)cc2)O1 |t:8| Show InChI InChI=1S/C21H23FN2O2/c1-14-8-10-25-21(26-14)9-7-16-11-19-15(12-20(16,21)2)13-23-24(19)18-5-3-17(22)4-6-18/h3-6,11,13-14H,7-10,12H2,1-2H3/t14-,20+,21+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human glucocorticoid receptor alpha isoform				Bioorg Med Chem Lett 15: 2926-31 (2005) Article DOI: 10.1016/j.bmcl.2005.03.027 BindingDB Entry DOI: 10.7270/Q2X34X0Q
					More data for this Ligand-Target Pair