null

SMILES: COc1ccc2cc(ccc2c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=KGMQZDDEZWQXHM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50168090   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon receptor (Homo sapiens (Human))	BDBM50168090 (CHEMBL3799468) Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C33H27Cl2N3O4/c1-42-27-7-4-19-12-22(3-2-20(19)16-27)31-18-29(24-14-25(34)17-26(35)15-24)37-38(31)30-9-6-21-13-23(5-8-28(21)30)33(41)36-11-10-32(39)40/h2-5,7-8,12-18,30H,6,9-11H2,1H3,(H,36,41)(H,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...				Bioorg Med Chem 24: 2852-63 (2016) BindingDB Entry DOI: 10.7270/Q27P919J
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50168090 (CHEMBL3799468) Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C33H27Cl2N3O4/c1-42-27-7-4-19-12-22(3-2-20(19)16-27)31-18-29(24-14-25(34)17-26(35)15-24)37-38(31)30-9-6-21-13-23(5-8-28(21)30)33(41)36-11-10-32(39)40/h2-5,7-8,12-18,30H,6,9-11H2,1H3,(H,36,41)(H,39,40)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method				Bioorg Med Chem 24: 2852-63 (2016) BindingDB Entry DOI: 10.7270/Q27P919J
					More data for this Ligand-Target Pair