BDBM50168408 4-(5-Ethoxycarbamoyl-2,4-difluoro-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester::CHEMBL195853

SMILES: CCONC(=O)c1cc(Nc2ncnn3cc(C(=O)OCC)c(C(C)C)c23)c(F)cc1F

InChI Key: InChIKey=IMJDWAAISYUCKT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50168408   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168408 (4-(5-Ethoxycarbamoyl-2,4-difluoro-phenylamino)-5-i...) Show SMILES CCONC(=O)c1cc(Nc2ncnn3cc(C(=O)OCC)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C21H23F2N5O4/c1-5-31-21(30)13-9-28-18(17(13)11(3)4)19(24-10-25-28)26-16-7-12(14(22)8-15(16)23)20(29)27-32-6-2/h7-11H,5-6H2,1-4H3,(H,27,29)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair