BDBM50168417 CHEMBL192318::[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 3-piperidin-1-yl-propyl ester

SMILES: CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)c(F)cc1F

InChI Key: InChIKey=LMHPBVGQEGWFGF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50168417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168417 (CHEMBL192318 | [4-(2,4-Difluoro-5-methoxycarbamoyl...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C26H33F2N7O4/c1-16(2)22-21(32-26(37)39-11-7-10-34-8-5-4-6-9-34)14-35-23(22)24(29-15-30-35)31-20-12-17(25(36)33-38-3)18(27)13-19(20)28/h12-16H,4-11H2,1-3H3,(H,32,37)(H,33,36)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor (Homo sapiens (Human))	BDBM50168417 (CHEMBL192318 | [4-(2,4-Difluoro-5-methoxycarbamoyl...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCN4CCCCC4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C26H33F2N7O4/c1-16(2)22-21(32-26(37)39-11-7-10-34-8-5-4-6-9-34)14-35-23(22)24(29-15-30-35)31-20-12-17(25(36)33-38-3)18(27)13-19(20)28/h12-16H,4-11H2,1-3H3,(H,32,37)(H,33,36)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair