BDBM50168419 4-(4-Bromo-3-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester::CHEMBL193256::ethyl 4-(4-bromo-3-(methoxycarbamoyl)phenylamino)-5-isopropylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
SMILES: CCOC(=O)c1cn2ncnc(Nc3ccc(Br)c(c3)C(=O)NOC)c2c1C(C)C
InChI Key: InChIKey=AYJHNMSIZGHINI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50168419 (4-(4-Bromo-3-methoxycarbamoyl-phenylamino)-5-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University Curated by ChEMBL | Assay Description Inhibition of KDR | Bioorg Med Chem Lett 17: 2126-33 (2007) Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50168419 (4-(4-Bromo-3-methoxycarbamoyl-phenylamino)-5-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1) | J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN | |||||||||||
More data for this Ligand-Target Pair |