null

SMILES: NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-n3cccn3)c2)c1

InChI Key: InChIKey=NKBBUHVASSDOFU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50168490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50168490 (CHEMBL3805630) Show SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-n3cccn3)c2)c1 Show InChI InChI=1S/C23H19N5O3/c24-22(29)18-12-21(14-25-13-18)31-15-16-3-1-4-19(11-16)27-23(30)17-5-7-20(8-6-17)28-10-2-9-26-28/h1-14H,15H2,(H2,24,29)(H,27,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate inc...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM50168490 (CHEMBL3805630) Show SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-n3cccn3)c2)c1 Show InChI InChI=1S/C23H19N5O3/c24-22(29)18-12-21(14-25-13-18)31-15-16-3-1-4-19(11-16)27-23(30)17-5-7-20(8-6-17)28-10-2-9-26-28/h1-14H,15H2,(H2,24,29)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of human SIRT3 (102 to 399 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50168490 (CHEMBL3805630) Show SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-n3cccn3)c2)c1 Show InChI InChI=1S/C23H19N5O3/c24-22(29)18-12-21(14-25-13-18)31-15-16-3-1-4-19(11-16)27-23(30)17-5-7-20(8-6-17)28-10-2-9-26-28/h1-14H,15H2,(H2,24,29)(H,27,30)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate in...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair