BindingDB logo
myBDB logout

BDBM50168632 (S)-3-{Methyl-[5-(2-trifluoromethyl-phenyl)-thiophene-2-carbonyl]-amino}-pyrrolidine-1-carboxylic acid methyl-((R)-1-methyl-pyrrolidin-3-yl)-amide::CHEMBL364134

SMILES: CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=MFRUFOHSOXJFRJ-SJORKVTESA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50168632   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))		BDBM50168632
PNG
((S)-3-{Methyl-[5-(2-trifluoromethyl-phenyl)-thioph...)
Show SMILES CN([C@@H]1CCN(C)C1)C(=O)N1CC[C@@H](C1)N(C)C(=O)c1ccc(s1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H29F3N4O2S/c1-28-12-10-16(14-28)30(3)23(33)31-13-11-17(15-31)29(2)22(32)21-9-8-20(34-21)18-6-4-5-7-19(18)24(25,26)27/h4-9,16-17H,10-15H2,1-3H3/t16-,17+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 61n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...

Bioorg Med Chem Lett 15: 3439-45 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.015
BindingDB Entry DOI: 10.7270/Q2T72H0F
More data for this
Ligand-Target Pair