null

SMILES: NC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cncc(c2)C(N)=O)c1

InChI Key: InChIKey=RDIJGHJHZPQSKV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50168846   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM50168846 (CHEMBL3805304) Show SMILES NC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cncc(c2)C(N)=O)c1 Show InChI InChI=1S/C21H18N4O4/c22-19(26)14-4-6-15(7-5-14)21(28)25-17-3-1-2-13(8-17)12-29-18-9-16(20(23)27)10-24-11-18/h1-11H,12H2,(H2,22,26)(H2,23,27)(H,25,28)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate in...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50168846 (CHEMBL3805304) Show SMILES NC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cncc(c2)C(N)=O)c1 Show InChI InChI=1S/C21H18N4O4/c22-19(26)14-4-6-15(7-5-14)21(28)25-17-3-1-2-13(8-17)12-29-18-9-16(20(23)27)10-24-11-18/h1-11H,12H2,(H2,22,26)(H2,23,27)(H,25,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate inc...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM50168846 (CHEMBL3805304) Show SMILES NC(=O)c1ccc(cc1)C(=O)Nc1cccc(COc2cncc(c2)C(N)=O)c1 Show InChI InChI=1S/C21H18N4O4/c22-19(26)14-4-6-15(7-5-14)21(28)25-17-3-1-2-13(8-17)12-29-18-9-16(20(23)27)10-24-11-18/h1-11H,12H2,(H2,22,26)(H2,23,27)(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of human SIRT3 (102 to 399 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence...				J Med Chem 59: 2928-41 (2016) Article DOI: 10.1021/acs.jmedchem.5b01376 BindingDB Entry DOI: 10.7270/Q2Z89F9W
					More data for this Ligand-Target Pair