BDBM50168905 CHEMBL3805692
SMILES: NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)N3CCOCC3)c2)c1
InChI Key: InChIKey=VKLKXFOZNHEBSW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-3 (SIRT3) (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT3 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent deacetylase sirtuin 2 (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate in... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-3 (SIRT3) (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human SIRT3 (102 to 399 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate inc... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) (Homo sapiens (Human)) | BDBM50168905 (CHEMBL3805692) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His-tagged SIRT5 (37 to 310 residues) expressed in Escherichia coli using Ac-Lys(Succ)-AMC as substrate in... | J Med Chem 59: 2928-41 (2016) BindingDB Entry DOI: 10.7270/Q2Z89F9W | |||||||||||
More data for this Ligand-Target Pair |