BDBM50169696 (4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine::CHEMBL181742
SMILES: Clc1cc(Nc2ncnc3nn4ccccc4c23)ccc1OCc1ccccc1
InChI Key: InChIKey=SXKKJDFMAPGQSG-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50169696 ((4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-f...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.5 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5 | Bioorg Med Chem Lett 15: 3778-81 (2005) Article DOI: 10.1016/j.bmcl.2005.05.100 BindingDB Entry DOI: 10.7270/Q2P84BDM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50169696 ((4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-f...) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibitory concentration against ErbB-2 protein tyrosine kinase by using [gamma-33P]-ATP as radioligand in pH 7.5 | Bioorg Med Chem Lett 15: 3778-81 (2005) Article DOI: 10.1016/j.bmcl.2005.05.100 BindingDB Entry DOI: 10.7270/Q2P84BDM | |||||||||||
More data for this Ligand-Target Pair |