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BDBM50170270 CHEMBL182530::S(-)nicotine-B

SMILES: CN1CCC[C@H]1c1ccc[n+](BC#N)c1

InChI Key: InChIKey=JWLGWAGDGPBUQT-NSHDSACASA-N

Data: 2 KI 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50170270
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha7 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-3/Beta-4 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha3-beta4 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha4-beta2 nicotinic acetylcholinereceptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair