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BDBM50170317 1-(2,2-Dimethyl-propyl)-4-propyl-5-{3-[4-(1H-tetrazol-5-yl)-phenoxy]-benzyloxy}-1H-indole::CHEMBL185659

SMILES: CCCc1c(OCc2cccc(Oc3ccc(cc3)-c3nnn[nH]3)c2)ccc2n(CC(C)(C)C)ccc12

InChI Key: InChIKey=KBZHMHKYIFBNTJ-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50170317   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50170317
PNG
(1-(2,2-Dimethyl-propyl)-4-propyl-5-{3-[4-(1H-tetra...)
Show SMILES CCCc1c(OCc2cccc(Oc3ccc(cc3)-c3nnn[nH]3)c2)ccc2n(CC(C)(C)C)ccc12
Show InChI InChI=1S/C30H33N5O2/c1-5-7-26-25-16-17-35(20-30(2,3)4)27(25)14-15-28(26)36-19-21-8-6-9-24(18-21)37-23-12-10-22(11-13-23)29-31-33-34-32-29/h6,8-18H,5,7,19-20H2,1-4H3,(H,31,32,33,34)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 451n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human metabotropic glutamate receptor 2 incubated at 30 degree C for 1 hr


Bioorg Med Chem Lett 15: 4068-72 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.017
BindingDB Entry DOI: 10.7270/Q2Q52P6K
More data for this
Ligand-Target Pair