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BDBM50170892 CHEMBL3804861

SMILES: CC(NCC(N)P(O)(O)=O)c1ccccc1

InChI Key: InChIKey=LRYVOWVFITYCIO-UHFFFAOYNA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50170892   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Homo sapiens (Human))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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391n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition mea...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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2.80E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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UniChem

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PubMed
1.45E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured f...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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Article
PubMed
>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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Article
PubMed
>2.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric met...


Bioorg Med Chem Lett 26: 4122-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.06.062
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

PubMed
6.00E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair