BDBM50171515 CHEMBL190651::N-[4-(4,5-Dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide
SMILES: COCC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
InChI Key: InChIKey=BOTQXVZWXJGWAV-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >250 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of HER1 kinase in intact DHER14 cells | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 252 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 10000-50000 nM | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of human PDGFR kinase in intact NIHPDGFR cells | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of HER2 kinase in intact CSH12 cells | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171515 (CHEMBL190651 | N-[4-(4,5-Dichloro-2-fluoro-phenyla...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 1000-10000 nM | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair |