BDBM50172413 2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-methylamino-ethyl)-amino]-quinolin-6-yl}-acetamide::CHEMBL373084

SMILES: CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1

InChI Key: InChIKey=ZKAMUYRESJQUBC-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172413   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GPR145 (Homo sapiens (Human))	BDBM50172413 (2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...) Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50172413 (2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...) Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172413 (2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...) Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172413 (2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...) Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172413 (2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...) Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1 Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair