BDBM50173531 1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione::CHEMBL197290::dUTPase inhibitor, 8
SMILES: OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O
InChI Key: InChIKey=HEOOHGVQTWVRSR-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
dUTP pyrophosphatase (Plasmodium falciparum) | BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.80E+3 | -7.57 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Instituto de Parastiologia y Biomedicina "Lopez-Neyra" | Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete... | J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human)) | BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.08E+5 | -4.15 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Instituto de Parastiologia y Biomedicina "Lopez-Neyra" | Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete... | J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Campylobacter jejuni) | BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.00E+9 | 0 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Instituto de Parastiologia y Biomedicina "Lopez-Neyra" | Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete... | J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST | |||||||||||
More data for this Ligand-Target Pair |