BDBM50173827 1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide::CHEMBL198263
SMILES: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C1CC1)NC(=O)[C@@H]1CCC(=O)N1
InChI Key: InChIKey=IZHGNNQVQWPRDQ-IHRRRGAJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyrotropin-releasing hormone receptor 2 (Rattus norvegicus) | BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor 2 (Rattus norvegicus) | BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 410 | n/a | n/a | 7.8 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50173827 (1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | 7.8 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair |